CENTRAL CARBON → PYRUVATE FAMILY → INDIVIDUAL PATHWAY

Alanine from pyruvate

Follow the carbon skeleton from Pyruvate + L-glutamate to L-Alanine + 2-oxoglutarate.

What it needs

Pyruvate and an amino-group donor such as glutamate.

What it supplies

L-Alanine + 2-oxoglutarate. This product can enter downstream cellular reactions; its synthesis depends on the precursor and helper supplies shown.

The pathway

Read from top to bottom. Select an enzyme box to jump to its reaction. Cosubstrates and selected coproducts appear in the account below.

Open full-resolution vector diagram ↗

Reactions and enzymes

1 · Alanine aminotransferase

Pyruvate + L-glutamate → L-Alanine + 2-oxoglutarate

Alanine aminotransferase · EC 2.6.1.2

Inputs, helpers or coproducts: PLP-dependent amino-group transfer

Connected pathways

Glutamate and nitrogen assimilation Valine biosynthesis Leucine biosynthesis

Evidence and scope

Transamination is one route to L-alanine. Alanine dehydrogenase and other reactions provide alternatives; D-alanine for cell walls is a separate conversion. This page explains selected documented biochemical reactions. It does not establish that every displayed enzyme occurs in Aquifex, that the pathway is universally essential, or that the book image records a complete organism. Gene symbols name common enzyme activities; organism-specific protein records require separate matching.

Original explanatory diagram and reaction account, based on the records below. Arrows show the biosynthetic reading direction; they do not claim that every reaction is irreversible. Selected protons, water and cofactors are omitted from the overview and are not implied absent.

KEGG ec:2.6.1.2 · pathway / enzyme record