CENTRAL CARBON → OXALOACETATE FAMILY → INDIVIDUAL PATHWAY

Aspartate from oxaloacetate

Follow the carbon skeleton from Oxaloacetate + L-glutamate to L-Aspartate + 2-oxoglutarate.

What it needs

Oxaloacetate from central carbon metabolism and glutamate as an amino-group donor.

What it supplies

L-Aspartate + 2-oxoglutarate. This product can enter downstream cellular reactions; its synthesis depends on the precursor and helper supplies shown.

The pathway

Read from top to bottom. Select an enzyme box to jump to its reaction. Cosubstrates and selected coproducts appear in the account below.

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Reactions and enzymes

1 · Aspartate aminotransferase

Oxaloacetate + L-glutamate → L-Aspartate + 2-oxoglutarate

Aspartate aminotransferase · EC 2.6.1.1

Inputs, helpers or coproducts: PLP-dependent amino-group transfer

Connected pathways

Asparagine biosynthesis Threonine biosynthesis Methionine biosynthesis Lysine biosynthesis

Evidence and scope

The reaction connects central carbon to amino-acid and nucleotide synthesis. Aspartate can feed several downstream pathways. This page explains selected documented biochemical reactions. It does not establish that every displayed enzyme occurs in Aquifex, that the pathway is universally essential, or that the book image records a complete organism. Gene symbols name common enzyme activities; organism-specific protein records require separate matching.

Original explanatory diagram and reaction account, based on the records below. Arrows show the biosynthetic reading direction; they do not claim that every reaction is irreversible. Selected protons, water and cofactors are omitted from the overview and are not implied absent.

KEGG ec:2.6.1.1 · pathway / enzyme record