CENTRAL CARBON → ASPARTATE FAMILY → INDIVIDUAL PATHWAY

Asparagine biosynthesis

Follow the carbon skeleton from L-Aspartate + L-glutamine + ATP to L-Asparagine + L-glutamate.

What it needs

Aspartate, ATP and glutamine-derived nitrogen.

What it supplies

L-Asparagine + L-glutamate. This product can enter downstream cellular reactions; its synthesis depends on the precursor and helper supplies shown.

The pathway

Read from top to bottom. Select an enzyme box to jump to its reaction. Cosubstrates and selected coproducts appear in the account below.

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Reactions and enzymes

1 · Asparagine synthetase B (AsnB)

L-Aspartate + L-glutamine + ATP → L-Asparagine + L-glutamate

Asparagine synthetase B (AsnB) · EC 6.3.5.4

Inputs, helpers or coproducts: ATP → AMP + PPᵢ; water participates

Connected pathways

Aspartate from oxaloacetate Glutamine biosynthesis

Evidence and scope

An ammonia-dependent asparagine synthetase (AsnA, EC 6.3.1.1) is another option. Some organisms use tRNA-dependent indirect synthesis. This page explains selected documented biochemical reactions. It does not establish that every displayed enzyme occurs in Aquifex, that the pathway is universally essential, or that the book image records a complete organism. Gene symbols name common enzyme activities; organism-specific protein records require separate matching.

Original explanatory diagram and reaction account, based on the records below. Arrows show the biosynthetic reading direction; they do not claim that every reaction is irreversible. Selected protons, water and cofactors are omitted from the overview and are not implied absent.

KEGG ec:6.3.5.4 · pathway / enzyme record