CENTRAL CARBON → SERINE / ONE-CARBON CONNECTION → INDIVIDUAL PATHWAY

Glycine from serine

Follow the carbon skeleton from L-Serine + tetrahydrofolate to Glycine + 5,10-methylene-THF.

What it needs

Serine, tetrahydrofolate and a PLP-dependent enzyme.

What it supplies

Glycine + 5,10-methylene-THF. This product can enter downstream cellular reactions; its synthesis depends on the precursor and helper supplies shown.

The pathway

Read from top to bottom. Select an enzyme box to jump to its reaction. Cosubstrates and selected coproducts appear in the account below.

Open full-resolution vector diagram ↗

Reactions and enzymes

1 · Serine hydroxymethyltransferase

L-Serine + tetrahydrofolate → Glycine + 5,10-methylene-THF

Serine hydroxymethyltransferase · EC 2.1.2.1

Inputs, helpers or coproducts: PLP cofactor; water released

The reaction is reversible and transfers a one-carbon unit to THF.

Connected pathways

Serine biosynthesis Glutamate and nitrogen assimilation

Evidence and scope

This shows one glycine-producing route. The glycine cleavage system and other routes are separate; their direction depends on context. This page explains selected documented biochemical reactions. It does not establish that every displayed enzyme occurs in Aquifex, that the pathway is universally essential, or that the book image records a complete organism. Gene symbols name common enzyme activities; organism-specific protein records require separate matching.

Original explanatory diagram and reaction account, based on the records below. Arrows show the biosynthetic reading direction; they do not claim that every reaction is irreversible. Selected protons, water and cofactors are omitted from the overview and are not implied absent.

KEGG ec:2.1.2.1 · pathway / enzyme record