Evidence and scope
The 2-oxoisovalerate intermediate also feeds the leucine branch. Enzyme-subunit organization varies. This page explains selected documented biochemical reactions. It does not establish that every displayed enzyme occurs in Aquifex, that the pathway is universally essential, or that the book image records a complete organism. Gene symbols name common enzyme activities; organism-specific protein records require separate matching.
Original explanatory diagram and reaction account, based on the records below. Arrows show the biosynthetic reading direction; they do not claim that every reaction is irreversible. Selected protons, water and cofactors are omitted from the overview and are not implied absent.
Compare the related Aquifex annotation group →