Pathway · 31 proteins
Not yet placed in a pathway
Proteins of this group that neither the atlas’s curated pathways nor a KEGG pathway map place yet.
How it works
Each still has a group in the Aquifex reconstruction.
Its proteins
| Protein | EC | Reaction (UniProt) | Metal or cluster | Amino acids | Certainty |
|---|---|---|---|---|---|
| NAD-independent protein lysine deacetylase | — | N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate | Zn(2+) | 375 | System only |
| Selenide, water dikinase | 2.7.9.3 | hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+) | Mg(2+) | 336 | Step named |
| Twin-arginine translocation signal domain-containing protein | — | — | — | 124 | System only |
| Phosphohistidine phosphatase SixA | — | — | — | 149 | System only |
| Polymerase/histidinol phosphatase N-terminal domain-containing protein | — | — | — | 247 | System only |
| Peptidase S54 rhomboid domain-containing protein | — | — | — | 227 | System only |
| Uncharacterized HIT-like protein aq_141 | — | — | — | 121 | Step named |
| Methyltransferase domain-containing protein | — | — | — | 210 | System only |
| O-methyltransferase | — | — | — | 212 | System only |
| N-acetylmuramoyl-L-alanine amidase | 3.5.1.28 | Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. | — | 359 | Step named |
| Transcriptional regulator (DegT/DnrJ/Eryc1 family) | — | — | — | 346 | System only |
| Cyclopropane-fatty-acyl-phospholipid synthase | — | — | — | 400 | System only |
| Phosphoglycerate mutase | — | — | — | 220 | Step named |
| Uncharacterized protein | — | — | [4Fe-4S] cluster | 342 | System only |
| Subtilisin-like protease | 3.4.-.- | — | — | 560 | Step named |
| Radical SAM core domain-containing protein | — | — | [4Fe-4S] cluster | 372 | Step named |
| non-specific serine/threonine protein kinase | 2.7.11.1 | — | — | 293 | Step named |
| Radical SAM core domain-containing protein | — | — | [4Fe-4S] cluster | 454 | System only |
| Proteinase IV | — | — | — | 283 | System only |
| Probable cytosol aminopeptidase | 3.4.11.1; 3.4.11.10 | Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. | Mn(2+) | 493 | Step named |
| Uncharacterized protein | — | — | — | 251 | System only |
| Lon protease | 3.4.21.53 | Hydrolysis of proteins in presence of ATP. | — | 795 | Step named |
| Uncharacterized RNA methyltransferase aq_257 | 2.1.1.- | — | [4Fe-4S] cluster | 425 | Step named |
| Glutamine--fructose-6-phosphate aminotransferase [isomerizing] | 2.6.1.16 | D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate | — | 592 | Step named |
| protein-serine/threonine phosphatase | 3.1.3.16 | O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate | Mg(2+), Mn(2+) | 211 | Step named |
| Ser/thr protein kinase | — | — | — | 271 | System only |
| Uncharacterized lipoprotein aq_615 | — | — | — | 132 | Step named |
| Phosphotyrosine protein phosphatase I domain-containing protein | — | — | — | 142 | System only |
| Radical SAM core domain-containing protein | — | — | [4Fe-4S] cluster | 337 | System only |
| Carboxyl-terminal protease | — | — | — | 408 | System only |
| Polymerase/histidinol phosphatase N-terminal domain-containing protein | — | — | — | 343 | System only |
Origins
Pathway-level origins (discovery history, the prebiotic question, hurdles, and the two panels) are written in phase 3. Until then, see the origins for making the twenty amino acids.
Sources
Other pathways in this group: Aromatic amino acids · Branched-chain amino acids · Aspartate-family branches · Nitrogen assimilation · RNA maturation · Folate-linked carbon transfer · Arginine biosynthesis · Cysteine and methionine metabolism · Histidine metabolism · Lysine biosynthesis · Arginine and proline metabolism · Phenylalanine, tyrosine and tryptophan biosynthesis