Pathway · 37 proteins
Not yet placed in a pathway
Proteins of this group that neither the atlas’s curated pathways nor a KEGG pathway map place yet.
How it works
Each still has a group in the Aquifex reconstruction.
Its proteins
| Protein | EC | Reaction (UniProt) | Metal or cluster | Amino acids | Certainty |
|---|---|---|---|---|---|
| L-seryl-tRNA(Sec) selenium transferase | 2.9.1.1 | L-seryl-tRNA(Sec) + selenophosphate + H(+) = L-selenocysteinyl-tRNA(Sec) + phosphate | — | 452 | Step named |
| FAD:protein FMN transferase | 2.7.1.180 | L-threonyl-[protein] + FAD = FMN-L-threonyl-[protein] + AMP + H(+) | Mg(2+), Mn(2+) | 288 | Step named |
| Molybdopterin-synthase adenylyltransferase | 2.7.7.80 | [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate | Zn(2+) | 271 | Step named |
| Bifunctional NAD(P)H-hydrate repair enzyme Nnr | 4.2.1.136; 5.1.99.6 | (6S)-NADHX + ADP = AMP + phosphate + NADH + H(+) | K(+) | 499 | Step named |
| Putative sulfur carrier protein aq_1421 | — | — | — | 197 | Step named |
| Serine aminopeptidase S33 domain-containing protein | — | — | — | 226 | System only |
| Uncharacterized protein | — | — | — | 182 | System only |
| Alanine--glyoxylate aminotransferase family protein | — | — | — | 119 | System only |
| Metallo-beta-lactamase domain-containing protein | — | — | — | 249 | System only |
| Putative L-lysine 2,3-aminomutase aq_1632 | 5.4.3.- | — | [4Fe-4S] cluster | 374 | Step named |
| Lipoate-protein ligase A | — | — | — | 788 | Step named |
| Transketolase | 2.2.1.1 | D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate | D-xylulose 5-phosphate, Mg(2+), Ca(2+) | 689 | Step named |
| Beta lactamase | — | — | — | 326 | System only |
| Alanine racemase | 5.1.1.1 | L-alanine = D-alanine | — | 338 | Step named |
| Uncharacterized protein aq_1854 | — | — | heme c | 152 | Step named |
| Folate-binding protein YgfZ | — | — | — | 153 | System only |
| Thiamine-binding protein domain-containing protein | — | — | — | 157 | System only |
| Histidinol-phosphate aminotransferase | 2.6.1.9 | L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate | — | 354 | Step named |
| Aminotransferase | 2.6.1.- | — | — | 414 | Step named |
| Acetyl-coenzyme A synthetase c-terminal | — | — | — | 136 | System only |
| Uncharacterized globin-like protein aq_211 | — | — | — | 139 | Step named |
| Aldehyde dehydrogenase | — | — | — | 720 | System only |
| Pyridoxal phosphate homeostasis protein | — | — | — | 228 | Step named |
| 1,4-dihydroxy-6-naphtoate synthase | 4.1.99.29 | cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + dihydroxyacetone | — | 279 | Step named |
| AB hydrolase-1 domain-containing protein | — | — | — | 256 | System only |
| Aminotransferase (AspC family) | — | — | — | 373 | System only |
| Putative L-lysine 2,3-aminomutase aq_454 | 5.4.3.- | — | [4Fe-4S] cluster | 370 | Step named |
| Flavin-dependent thymidylate synthase | 2.1.1.148 | dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+) = dTMP + (6S)-5,6,7,8-tetrahydrofolate + NADP(+) | — | 317 | Step named |
| Ni/Fe hydrogenase B-type cytochrome subunit | — | — | — | 228 | Step named |
| Epoxyqueuosine reductase QueH | 1.17.99.6 | epoxyqueuosine(34) in tRNA + AH2 = queuosine(34) in tRNA + A + H2O | [4Fe-4S] cluster | 413 | Step named |
| Glycogen phosphorylase | 2.4.1.1 | [(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate | — | 692 | Step named |
| Ornithine decarboxylase | — | — | — | 390 | Step named |
| Periplasmic serine protease | — | — | — | 288 | System only |
| S-adenosylmethionine:tRNA ribosyltransferase-isomerase | 2.4.99.17 | 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = epoxyqueuosine(34) in tRNA + adenine + L-methionine + 2 H(+) | — | 334 | Step named |
| Thil AANH domain-containing protein | — | — | — | 251 | System only |
| Uncharacterized protein aq_928 | — | — | FMN | 196 | Step named |
| Beta lactamase | — | — | — | 307 | System only |
Origins
Pathway-level origins (discovery history, the prebiotic question, hurdles, and the two panels) are written in phase 3. Until then, see the origins for manufacturing cofactors and vitamins.
Sources
Other pathways in this group: Heme and quinones · Biotin and lipoate · NAD and flavins · Thiamine and pyridoxal · Folate and pterin chemistry · Lipid and cofactor connections · Coenzyme A · Aspartate-family branches · Amino-acid connections · Folate-linked carbon transfer · Serine, glycine and sulfur · Folate biosynthesis · Oxidative phosphorylation · Thiamine metabolism · Pantothenate and CoA biosynthesis · Glycine, serine and threonine metabolism · Riboflavin metabolism · Nicotinate and nicotinamide metabolism · Biotin metabolism · Cysteine and methionine metabolism · Porphyrin metabolism · Pyruvate metabolism