Pathway · 53 proteins
Not yet placed in a pathway
Proteins of this group that neither the atlas’s curated pathways nor a KEGG pathway map place yet.
How it works
Each still has a group in the Aquifex reconstruction.
Its proteins
| Protein | EC | Reaction (UniProt) | Metal or cluster | Amino acids | Certainty |
|---|---|---|---|---|---|
| Large ribosomal subunit protein uL22 | — | — | — | 133 | Step named |
| Large ribosomal subunit protein uL29 | — | — | — | 73 | Step named |
| Small ribosomal subunit protein bS18 | — | — | Zn(2+) | 72 | Step named |
| Sec-independent protein translocase protein TatA 1 | — | — | — | 59 | Step named |
| Sec-independent protein translocase protein TatA 2 | — | — | — | 77 | Step named |
| Translation initiation factor IF-1 | — | — | — | 80 | Step named |
| Methionine aminopeptidase | 3.4.11.18 | Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. | Co(2+), Zn(2+), Mn(2+) | 258 | Step named |
| Hydrogenase maturation factor HypA | — | — | Ni(2+), Zn(2+) | 115 | Step named |
| Large ribosomal RNA subunit accumulation protein YceD | — | — | — | 174 | System only |
| Endonuclease MutS2 | 3.1.-.-; 3.6.4.- | — | — | 762 | Step named |
| Ancillary SecYEG translocon subunit/Cell division coordinator CpoB TPR domain-containing protein | — | — | — | 217 | System only |
| Ribosomal silencing factor RsfS | — | — | — | 109 | System only |
| Small heat shock protein (Class I) | — | — | — | 144 | System only |
| Queuine tRNA-ribosyltransferase | 2.4.2.29 | 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine | Zn(2+) | 378 | Step named |
| Heme chaperone HemW | — | — | [4Fe-4S] cluster | 370 | System only |
| Cobalamin synthesis related protein CobW | — | GTP + H2O = GDP + phosphate + H(+) | — | 292 | System only |
| Deoxyribose-phosphate aldolase | 4.1.2.4 | 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde | — | 219 | Step named |
| Putative pre-16S rRNA nuclease | 3.1.-.- | — | — | 131 | Step named |
| Ribosome hibernation promoting factor | — | — | — | 218 | System only |
| Large ribosomal subunit protein bL21 | — | — | — | 98 | Step named |
| Small ribosomal subunit protein uS14 | — | — | Zn(2+) | 62 | Step named |
| Chaperone protein ClpB | — | — | — | 1006 | Step named |
| Small ribosomal subunit biogenesis GTPase RsgA | 3.6.1.- | — | Zn(2+) | 302 | Step named |
| Helicase HerA barrel domain-containing protein | — | — | — | 552 | System only |
| EngC GTPase domain-containing protein | — | — | — | 147 | System only |
| tRNA pseudouridine synthase D | 5.4.99.27 | uridine(13) in tRNA = pseudouridine(13) in tRNA | — | 385 | Step named |
| Chaperone protein DnaJ 1 | — | — | Zn(2+) | 364 | Step named |
| Large ribosomal subunit protein bL27 | — | — | — | 98 | Step named |
| Probable GTP-binding protein EngB | — | — | Mg(2+) | 183 | Step named |
| MgtC/SapB/SrpB/YhiD N-terminal domain-containing protein | — | — | — | 141 | System only |
| PLD phosphodiesterase domain-containing protein | — | — | — | 625 | System only |
| D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | (2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+) | — | 533 | Step named |
| GTPase HflX | — | — | Mg(2+) | 370 | System only |
| GTPase Der | — | — | — | 433 | Step named |
| Large ribosomal subunit protein bL33 | — | — | Zn(2+) | 50 | Step named |
| Protein translocase subunit SecE | — | — | — | 65 | Step named |
| GTPase Era | — | — | — | 301 | Step named |
| GTPase Obg | 3.6.5.- | — | Mg(2+) | 343 | Step named |
| CC-adding tRNA nucleotidyltransferase | 2.7.7.- | a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate | Mg(2+) | 512 | Step named |
| Small ribosomal subunit protein uS15 | — | — | — | 90 | Step named |
| Peptidyl-tRNA hydrolase | 3.1.1.29 | an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+) | tRNA | 192 | Step named |
| Probable dual-specificity RNA methyltransferase RlmN | 2.1.1.192 | adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine | [4Fe-4S] cluster | 348 | Step named |
| D-aminoacyl-tRNA deacylase | 3.1.1.96 | glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+) | — | 148 | Step named |
| [Ribosomal protein bS18]-alanine N-acetyltransferase | 2.3.1.266 | N-terminal L-alanyl-[ribosomal protein bS18] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18] + CoA + H(+) | — | 154 | Step named |
| Peptide deformylase | 3.5.1.88 | N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate | Fe cation, Fe(2+) | 169 | Step named |
| PpiC domain-containing protein | — | — | — | 437 | System only |
| Ribosome-binding ATPase YchF | — | — | Mg(2+) | 370 | System only |
| tRNA pseudouridine synthase B | 5.4.99.25 | uridine(55) in tRNA = pseudouridine(55) in tRNA | — | 287 | Step named |
| tRNA pseudouridine synthase A | 5.4.99.12 | uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA | — | 241 | Step named |
| Putative prefoldin subunit alpha | — | — | — | 149 | Step named |
| Large ribosomal subunit protein bL35 | — | — | — | 67 | Step named |
| Small ribosomal subunit protein bS21 | — | — | — | 67 | Step named |
| Large ribosomal subunit protein bL31 | — | — | Zn(2+) | 68 | Step named |
Origins
Pathway-level origins (discovery history, the prebiotic question, hurdles, and the two panels) are written in phase 3. Until then, see the origins for building proteins and folding them.
Sources
Other pathways in this group: Ribosomal subunits · Translation interface · RNA maturation · Translation cycle · Protein translocation · Protein turnover · Folding and stabilization · Recycling and rescue · Early folding support · Protein targeting · Ribosome · Protein export