Pathway · 68 proteins
Not yet placed in a pathway
Proteins of this group that neither the atlas’s curated pathways nor a KEGG pathway map place yet.
How it works
Each still has a group in the Aquifex reconstruction.
Its proteins
| Protein | EC | Reaction (UniProt) | Metal or cluster | Amino acids | Certainty |
|---|---|---|---|---|---|
| CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein | — | — | — | 166 | Unspecified |
| 3-hydroxyisobutyrate dehydrogenase | — | — | — | 288 | Unspecified |
| UPF0102 protein aq_041 | — | — | — | 103 | Unspecified |
| Sugar fermentation stimulation protein homolog | — | — | — | 214 | Unspecified |
| Polyamine aminopropyltransferase 1 | 2.5.1.16 | S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+) | — | 280 | Unspecified |
| Gcp-like domain-containing protein | — | — | — | 200 | Unspecified |
| Periplasmic divalent cation tolerance protein | — | — | — | 104 | Unspecified |
| Collagenase | — | — | — | 409 | Unspecified |
| Uncharacterized metallophosphoesterase aq_1054 | 3.1.-.- | — | — | 261 | Unspecified |
| Uncharacterized protein | — | — | — | 185 | Unspecified |
| DUF458 domain-containing protein | — | — | — | 146 | Unspecified |
| C4-type zinc ribbon domain-containing protein | — | — | — | 235 | Unspecified |
| tRNA-specific 2-thiouridylase MnmA | 2.8.1.13 | S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA + AH2 + ATP = 2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+) | — | 356 | Unspecified |
| Cytoplasmic axial filament protein | — | — | Mg(2+) | 458 | Unspecified |
| Nucleotide sugar epimerase | — | — | — | 321 | Unspecified |
| PspA/IM30 family protein | — | — | — | 234 | Unspecified |
| PhoH-like protein | — | — | — | 348 | Unspecified |
| N-acetyltransferase domain-containing protein | — | — | — | 181 | Unspecified |
| ADP-heptose:LPS heptosyltransferase | — | — | — | 317 | Unspecified |
| Uncharacterized RNA pseudouridine synthase aq_1464 | 5.4.99.- | a uridine in RNA = a pseudouridine in RNA | — | 249 | Unspecified |
| Putative esterase aq_1494 | 3.1.-.- | — | — | 128 | Unspecified |
| Mce/MlaD domain-containing protein | — | — | — | 300 | Unspecified |
| DUF420 domain-containing protein | — | — | — | 132 | Unspecified |
| Probable tRNA-dihydrouridine synthase | 1.3.1.- | a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + NADH + H(+) | FMN | 316 | Unspecified |
| Type 4 prepilin peptidase | — | — | — | 254 | Unspecified |
| UPF0758 protein aq_1610 | — | — | Zn(2+) | 231 | Unspecified |
| Uncharacterized protein | — | — | — | 325 | Unspecified |
| dTTP/UTP pyrophosphatase | 3.6.1.9 | dTTP + H2O = dTMP + diphosphate + H(+) | — | 190 | Unspecified |
| DUF507 family protein | — | — | — | 183 | Unspecified |
| N(4)-bis(aminopropyl)spermidine synthase | 2.5.1.128 | 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine + 2 H(+) | — | 355 | Unspecified |
| Uncharacterized RNA pseudouridine synthase aq_1758 | 5.4.99.- | a uridine in RNA = a pseudouridine in RNA | — | 316 | Unspecified |
| Nodulation competitiveness protein NfeD | — | — | — | 425 | Unspecified |
| Aldehyde dehydrogenase | — | — | — | 476 | Unspecified |
| CoA-binding domain-containing protein | — | — | — | 137 | Unspecified |
| Peptide maturation | — | — | — | 441 | Unspecified |
| HD domain-containing protein | — | — | Zn(2+) | 371 | Unspecified |
| Putative carboxymethylenebutenolidase | 3.1.1.45 | 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+) | — | 231 | Unspecified |
| TldD protein | — | — | — | 404 | Unspecified |
| Cyanate hydratase | 4.2.1.104 | cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2 | — | 149 | Unspecified |
| Archease domain-containing protein | — | — | — | 140 | Unspecified |
| Methionyl-tRNA formyltransferase | 2.1.2.9 | L-methionyl-tRNA(fMet) + (6R)-10-formyltetrahydrofolate = N-formyl-L-methionyl-tRNA(fMet) + (6S)-5,6,7,8-tetrahydrofolate + H(+) | — | 303 | Unspecified |
| Uncharacterized protein aq_2144 | — | — | — | 298 | Unspecified |
| Integration host factor beta subunit | — | — | — | 100 | Unspecified |
| AAA+ ATPase domain-containing protein | — | — | — | 300 | Unspecified |
| BFN domain-containing protein | — | — | — | 165 | Unspecified |
| SsrA-binding protein | — | — | — | 157 | Unspecified |
| Gluconokinase | — | — | — | 322 | Unspecified |
| AAA+ ATPase domain-containing protein | — | — | — | 492 | Unspecified |
| Methyltransferase type 11 domain-containing protein | — | — | — | 217 | Unspecified |
| RutC family protein aq_364 | — | — | — | 125 | Unspecified |
| Segregation and condensation protein A | — | — | — | 205 | Unspecified |
| Glycerol kinase | 2.7.1.30 | glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+) | — | 492 | Unspecified |
| Uncharacterized protein aq_453 | — | — | — | 257 | Unspecified |
| TolC family protein | — | — | — | 259 | Unspecified |
| Uncharacterized RNA pseudouridine synthase aq_554 | 5.4.99.- | a uridine in RNA = a pseudouridine in RNA | — | 238 | Unspecified |
| Protein kinase domain-containing protein | — | — | — | 192 | Unspecified |
| Type II/III secretion system secretin-like domain-containing protein | — | — | — | 705 | Unspecified |
| L-threonylcarbamoyladenylate synthase | 2.7.7.87 | L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O | — | 198 | Unspecified |
| D-lactate dehydrogenase | — | — | — | 334 | Unspecified |
| Fimbrial assembly protein PilC | — | — | — | 408 | Unspecified |
| RNA 2',3'-cyclic phosphodiesterase | 3.1.4.58 | a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) | — | 188 | Unspecified |
| Hemolysin | — | — | — | 258 | Unspecified |
| tRNA N6-adenosine threonylcarbamoyltransferase | 2.3.1.234 | L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+) | Fe cation, Fe(2+) | 335 | Unspecified |
| tRNA threonylcarbamoyladenosine biosynthesis protein TsaE | — | — | Mg(2+) | 133 | Unspecified |
| MEMO1 family protein aq_890 | — | — | — | 267 | Unspecified |
| Damage-control phosphatase ARMT1-like metal-binding domain-containing protein | — | — | — | 283 | Unspecified |
| tRNA-specific adenosine deaminase | 3.5.4.33 | adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+) | Zn(2+) | 151 | Unspecified |
| NurA domain-containing protein | — | — | — | 334 | Unspecified |
Origins
Pathway-level origins (discovery history, the prebiotic question, hurdles, and the two panels) are written in phase 3. Until then, see the origins for conserved, but we cannot say what they do.
Sources
Other pathways in this group: tRNA charging · Nutrient and metabolic state · Biosynthesis of various nucleotide sugars · Purine metabolism · Bacterial secretion system · Glyoxylate and dicarboxylate metabolism · Starch and sucrose metabolism · Homologous recombination · Fructose and mannose metabolism · Streptomycin biosynthesis · Other carbon fixation pathways · Nicotinate and nicotinamide metabolism